Comparison of macromolecular binding of estradiol in hormone-dependent and hormone-independent rat mammary carcinoma.
نویسندگان
چکیده
In rat mammary carcinoma, 2 types of cytoplasmic estradiol-binding sites, A and B, are present. The A sites are excluded on Sephadex G-100 chromatography, sediment at 8 S and 4 S in a low-ionic-strength sucrose gradient or at 4 S alone in a high-ionic-strength sucrose gradient, and form an insoluble complex with protamine sulfate. They have a very high affinity for estradiol (Kd ~ 1.2 X IO"10 M) and do not
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عنوان ژورنال:
- Cancer research
دوره 31 10 شماره
صفحات -
تاریخ انتشار 1971